Optimal production decisions in biopharmaceutical fill-and-finish operations

Incentive and production decisions for remanufacturing operations

Capital Structure Decisions in the Biopharmaceutical Industry

In this paper we deal with the capital structure problem in the pharmaceutical industry that has recently changed its business model because of the biotechnology advent. We propose a set of hypotheses that explains the drivers of capital structure decision in this industry and then we test their validity over a sample of 50 biopharmaceutical firms. The obtained results show that pecking order t...

Utilization of Site-Specific Recombination in Biopharmaceutical Production

Mammalian expression systems, due to their capacity in post-translational modification, are preferred systems for biopharmaceutical protein production. Several recombinant protein systems have been introduced to the market, most of which are under clinical development. In spite of significant improvements such as cell line engineering, introducing novel expression methods, gene silencing and pr...

Production Planning of Biopharmaceutical Manufacture

Multiproduct manufacturing facilities running on a campaign basis are increasingly becoming the norm for biopharmaceuticals, owing to high risks of clinical failure, regulatory pressures and the increasing number of therapeutics in clinical evaluation. The need for such flexible plants and cost-effective manufacture pose significant challenges for planning and scheduling, which are compounded b...

Optimal Production and Maintenance Planning of Biopharmaceutical Manufacturing under Performance Decay

Considering the performance decay of the chromatography resins in the downstream purification of biopharmaceutical manufacturing, the maintenance decisions should be made at appropriate times to achieve a good performance of the whole manufacturing process. In this paper, on the basis of the literature work on production planning, a mixed integer linear programming optimization model is develop...